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LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells.

Dong Hwan HoDaleum NamMi Kyoung SeoSung Woo ParkWongi SeolIlhong Son
Published in: Oxidative medicine and cellular longevity (2021)
Rotenone-induced upregulation of LRRK2 kinase activity promoted cellular senescence, which enhanced α-syn accumulation. However, the administration of an LRRK2 kinase inhibitor rejuvenated rotenone-induced cellular senescence.
Keyphrases
  • endothelial cells
  • high glucose
  • dna damage
  • diabetic rats
  • stress induced
  • induced apoptosis
  • cell proliferation
  • oxidative stress
  • cell cycle arrest
  • poor prognosis
  • cell death
  • tyrosine kinase
  • brain injury