The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy.
Chang GuanHai-Feng ZhangYa-Jing WangZhi-Teng ChenBing-Qing DengQiong QiuSi-Xu ChenMao-Xiong WuYang-Xin ChenJing-Feng WangPublished in: Oxidative medicine and cellular longevity (2021)
This study highlights that mCF ADAM17 expression plays a key role in cardiac fibrosis by regulating ER stress and mitophagy, thereby limiting fibrosis and improving heart function. Therefore, ADAM17 downregulation, within the physiological range, could exert protective effects against cardiac fibrosis.