RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes.
Jiazeng SunGuanhui WuFlorentin PastorNaimur RahmanWen-Hung WangZhengtao ZhangPhilippe MerleLijian HuiAnna SalvettiDavid DurantelDanzhou YangOurania M AndrisaniPublished in: Gut (2021)
RNA helicase DDX5 resolves a G-quadruplex structure in 5'UTR of STAT1 mRNA, enabling STAT1 translation. We propose that DDX5 is a key regulator of the dynamic range of IFN response during innate immunity and adjuvant IFN-α therapy.