Immunometabolism Modulation in Therapy.
Ezequiel MonferrerSabina SanegreIsaac Vieco-MartíAmparo López-CarrascoFernando FariñasAntonio VillatoroSergio AbanadesSantos MañesLuis de la Cruz MerinoRosa NogueraTomás Álvaro NaranjoPublished in: Biomedicines (2021)
The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, TAMs and DCs in cancer. We also discuss the extraordinary plasticity of the immune response and its implication in immunotherapy efficacy, and highlight different therapeutic intervention possibilities based on controlling the balanced systems of specific metabolites with antagonistic functions.
Keyphrases
- papillary thyroid
- randomized controlled trial
- immune response
- squamous cell
- induced apoptosis
- stem cells
- minimally invasive
- climate change
- ms ms
- squamous cell carcinoma
- childhood cancer
- lymph node metastasis
- bone marrow
- young adults
- dendritic cells
- inflammatory response
- human health
- mesenchymal stem cells
- cell therapy
- cell death
- anti inflammatory
- replacement therapy