Twenty-four-hour pretreatment with low dose (0.25 mg/kg/dose) versus high dose (0.5 mg/kg/dose) dexamethasone in reducing the risk of postextubation airway obstruction in children: A randomized open-label noninferiority trial.

Biraj Parajuli Arun Kumar Baranwal Praveen Kumar-M Muralidharan Jayashree Lalit Takia

Published in: Pediatric pulmonology (2021)

LDD (n = 144) or HDD (n = 143) (q6h) for a total of six doses. Extubation was planned immediately after fifth dose. Noninferiority margin was kept at 12% from baseline.

Keyphrases

high dose
low dose
open label
stem cell transplantation
clinical trial
phase iii
phase ii
study protocol
young adults
blood pressure
randomized controlled trial
squamous cell carcinoma
mechanical ventilation
respiratory failure
extracorporeal membrane oxygenation
placebo controlled