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Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter.

Walter BlumLászló PeczeJanine Wörthmüller RodriguezMartine SteinauerBeat Schwaller
Published in: BMC cancer (2018)
Our results demonstrate septin 7 not only serving as a "cytoskeletal" protein, but also as a transcription factor repressing calretinin expression. The negative regulation of calretinin by septin 7 and vice versa sheds new light on mechanisms possibly implicated in MM formation and identifies these proteins as transcriptional regulators and putative targets for MM therapy.
Keyphrases
  • transcription factor
  • dna binding
  • poor prognosis
  • gene expression
  • binding protein
  • dna methylation
  • genome wide
  • genome wide identification
  • protein protein
  • small molecule
  • smoking cessation
  • heat shock