Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease.

Anjali SadhwaniDavid WypijValerie RofebergAli GholipourMaggie MittlemanJulia RohdeClemente Velasco-AnnisJohanna CalderonKevin G FriedmanWayne TworetzkyPatricia Ellen Grant Janet S Soul Simon K Warfield Jane W NewburgerCynthia M OrtinauCaitlin K Rollins

Published in: Circulation (2022)

Small fetal brain volume is a strong independent predictor of 2-year neurodevelopmental outcomes and may be an important imaging biomarker of future neurodevelopmental risk in CHD. Future studies are needed to support this hypothesis. Our findings support inclusion of fetal brain volume in risk stratification models and as a possible outcome in fetal neuroprotective intervention studies.

Keyphrases

congenital heart disease
resting state
white matter
cerebral ischemia
functional connectivity
randomized controlled trial
current status
high resolution
case control
type diabetes
multiple sclerosis
brain injury
blood brain barrier
insulin resistance
fluorescence imaging