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Insulin sensitivity and beta cell function after duodenal mucosal resurfacing: an open-label, mechanistic, pilot study.

Celine B E BuschSuzanne MeiringAnnieke C G van BaarAmalia GastaldelliRalph DeFronzoGeltrude MingroneMoira HagenKelly WhiteHarith RajagopalanMax NieuwdorpJacques J G H M Bergman
Published in: Gastrointestinal endoscopy (2024)
Insulin sensitivity and insulin secretion improved 3 months after DMR. It is unlikely that incretin changes are responsible for improved glucose control after DMR. These data add to the growing evidence validating the duodenum as a therapeutic target for patients with T2D. (Clinical trial registration numbers: NCT02413567 and NCT03653091.).
Keyphrases
  • clinical trial
  • electronic health record
  • big data
  • blood glucose
  • study protocol
  • randomized controlled trial
  • metabolic syndrome
  • ulcerative colitis
  • machine learning
  • adipose tissue
  • data analysis
  • skeletal muscle