Corresponding Changes of Autophagy-Related Genes and Proteins in Different Stages of Knee Osteoarthritis: An Animal Model Study.

Shao-Long Zhang Ke-Shi ZhangJun-Feng WangYi-Chuan WangHui ZhangChong TangZheng PeiZhen-Peng Guan

Published in: Orthopaedic surgery (2022)

The expression of autophagy varies during different stages of osteoarthritis, in which the autophagy is stronger in the early stage of osteoarthritis, and gradually decreases with the progression of the disease. Autophagy in different weight-bearing areas may also be different.

Keyphrases

knee osteoarthritis
cell death
endoplasmic reticulum stress
early stage
signaling pathway
oxidative stress
rheumatoid arthritis
poor prognosis
body mass index
squamous cell carcinoma
radiation therapy
body weight