The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes.
Anne RabenPia Siig VestentoftJennie C Brand-MillerElli JaloMathjis DrummenElizabeth J SimpsonJosé Alfredo Martínez HernándezTeodora Handjieva-DarlenskaGareth StrattonMaija Huttunen-LenzTony LamJouko SundvallRoslyn MuirheadSally D PoppittChristian RitzKirsi H PietiläinenMargriet S Westerterp-PlantengaMoira A TaylorSantiago Navas-CarreteroSvetoslav HandjievMelitta Anne McNarrySylvia HansenLaura RåmanShannon BrodieMarta P SilvestreTanja C AdamIan A MacdonaldRodrigo San-CristóbalNadka BoyadjievaKelly Alexandra MackintoshWolfgang SchlichtAmy LiuThomas Meinert LarsenMikael FogelholmPublished in: Diabetes, obesity & metabolism (2020)
Three-year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating and PA was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.
Keyphrases
- weight loss
- physical activity
- phase iii
- randomized controlled trial
- bariatric surgery
- phase ii
- roux en y gastric bypass
- open label
- type diabetes
- protein protein
- gastric bypass
- clinical trial
- study protocol
- double blind
- amino acid
- binding protein
- risk factors
- body mass index
- placebo controlled
- depressive symptoms
- small molecule
- obese patients
- sleep quality
- weight gain