The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes.

Anne Raben Pia Siig Vestentoft Jennie C Brand-Miller Elli Jalo Mathjis Drummen Elizabeth J Simpson José Alfredo Martínez Hernández Teodora Handjieva-Darlenska Gareth Stratton Maija Huttunen-Lenz Tony LamJouko SundvallRoslyn Muirhead Sally D Poppitt Christian RitzKirsi H PietiläinenMargriet S Westerterp-PlantengaMoira A TaylorSantiago Navas-Carretero Svetoslav Handjiev Melitta Anne McNarry Sylvia HansenLaura RåmanShannon Brodie Marta P SilvestreTanja C AdamIan A Macdonald Rodrigo San-CristóbalNadka BoyadjievaKelly Alexandra Mackintosh Wolfgang SchlichtAmy LiuThomas Meinert Larsen Mikael Fogelholm

Published in: Diabetes, obesity & metabolism (2020)

Three-year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating and PA was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.

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