Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis.
Gretchen M AliceaPayal PatelMarie E PortualloMitchell E FaneMeihan WeiYash ChhabraAgrani DixitAlexis E CareyVania WangMurilo Ramos RochaReeti BeheraDavid W SpeicherHsin-Yao TangAndrew V KossenkovVito W RebeccaDenis WirtzAshani T WeeraratnaPublished in: Cancer research communications (2024)
The aged microenvironment drives metastasis in melanoma cells. This study reports that IGFBP2 secretion by aged fibroblasts induces lipid accumulation in melanoma cells, driving an increase in tumor invasiveness. Neutralizing IGFBP2 decreases melanoma tumor growth and metastasis.