Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken.

Ute MathisMarita FeldkaemperMin WangFrank Schaeffel

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2019)

Merging our results with published data, it can be concluded that both muscarinic and α2A-adrenergic receptors are expressed on dopaminergic neurons and both atropine and α2A-ADR antagonists stimulate DA release whereas α2A-ADR agonists strongly suppress its release. Stimulation of DA by atropine was enhanced by bright light. Results are in line with the hypothesis that inhibition of deprivation myopia is correlated with DA stimulation, as long as no toxicity is involved.

Keyphrases

optic nerve
adverse drug
optical coherence tomography
electronic health record
diabetic retinopathy
oxidative stress
spinal cord
big data
systematic review
randomized controlled trial
case control
spinal cord injury
meta analyses
oxide nanoparticles