Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer's Disease.
Nathanael MateiSophie LeahyNorman P BlairJames BurfordMansour RahimiMahnaz ShahidiPublished in: Cells (2022)
Concurrent alterations in retinal hemodynamic and oxygen metrics, thickness, and tissue Aβ42 protein levels in 5XFAD mice at 3 months of age corresponded to previously reported findings in human AD. Overall, these results suggest that this mouse model can be utilized for studying pathophysiology of AD and evaluating potential therapies.
Keyphrases
- mouse model
- optical coherence tomography
- diabetic retinopathy
- endothelial cells
- optic nerve
- induced pluripotent stem cells
- cognitive decline
- locally advanced
- high fat diet induced
- pluripotent stem cells
- squamous cell carcinoma
- amino acid
- human health
- binding protein
- adipose tissue
- risk assessment
- small molecule
- rectal cancer