Stimulatory and inhibitory effects of steroid hormones and human cytochrome P450 (CYP) 3A inhibitors on cortisol 6β-hydroxylation catalyzed by CYP3A subfamilies.

Toshiro NiwaMisaki TaniAnna SuzukiMizuho Murakami

Published in: Drug metabolism and bioanalysis letters (2023)

The inhibitory/stimulatory pattern among CYP3A subfamily members differed between cortisol and testosterone, and CYP3A4 was found to be the most sensitive in terms of inhibition by azole antifungals among the CYP3A subfamily members investigated.

Keyphrases

endothelial cells
induced pluripotent stem cells
candida albicans
genome wide identification
pluripotent stem cells
room temperature
replacement therapy
atomic force microscopy
transcription factor
mass spectrometry