Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies.
Yang YangHideyuki KogaYusuke NakagawaTomomasa NakamuraHiroki KatagiriRyohei TakadaMai KatakuraKunikazu TsujiIchiro SekiyaKazumasa MiyatakePublished in: Arthritis research & therapy (2024)
Upregulation of AP-1 family genes in the synovium and increased concentrations of CXCL8, MMP9, and VEGF were detected in the synovial fluid of the hypertrophic group of HOA patients, potentially stimulating the differentiation of SMSCs towards the cartilage and thereby contributing to severe osteophyte formation.
Keyphrases
- mesenchymal stem cells
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- stem cells
- prognostic factors
- genome wide
- poor prognosis
- cell proliferation
- rheumatoid arthritis
- endothelial cells
- umbilical cord
- early onset
- bone mineral density
- vascular endothelial growth factor
- signaling pathway
- patient reported outcomes
- soft tissue
- body composition
- long non coding rna
- cell migration
- cell therapy