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Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies.

Yang YangHideyuki KogaYusuke NakagawaTomomasa NakamuraHiroki KatagiriRyohei TakadaMai KatakuraKunikazu TsujiIchiro SekiyaKazumasa Miyatake
Published in: Arthritis research & therapy (2024)
Upregulation of AP-1 family genes in the synovium and increased concentrations of CXCL8, MMP9, and VEGF were detected in the synovial fluid of the hypertrophic group of HOA patients, potentially stimulating the differentiation of SMSCs towards the cartilage and thereby contributing to severe osteophyte formation.
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