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Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors.

Shirley TenesacaMarcos VasquezMaite AlvarezItziar OtanoMyriam Fernandez-SendinClaudia Augusta Di TraniNuria ArdaizCelia GomarAngela BellaFernando ArandaJosé Medina-EcheverzIgnacio Melero BermejoPedro Berraondo
Published in: Journal for immunotherapy of cancer (2022)
In conclusion, blockade of IFNα functions by simvastatin markedly enhances lymphocyte infiltration and the antitumor activity of MVA, prompting a feasible drug repurposing.
Keyphrases
  • dendritic cells
  • sars cov
  • cardiovascular disease
  • immune response
  • cerebral ischemia
  • peripheral blood
  • gene therapy
  • adverse drug
  • drug induced
  • emergency department
  • brain injury
  • blood brain barrier