Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors.
Shirley TenesacaMarcos VasquezMaite AlvarezItziar OtanoMyriam Fernandez-SendinClaudia Augusta Di TraniNuria ArdaizCelia GomarAngela BellaFernando ArandaJosé Medina-EcheverzIgnacio Melero BermejoPedro BerraondoPublished in: Journal for immunotherapy of cancer (2022)
In conclusion, blockade of IFNα functions by simvastatin markedly enhances lymphocyte infiltration and the antitumor activity of MVA, prompting a feasible drug repurposing.