SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis.

Lei FengKaikai ZhaoLiangchao SunXiaoyang YinJunpeng ZhangConghe LiuBaosheng Li

Published in: Journal of translational medicine (2021)

Our study reveals a connection between high SLC7A11 expression and NRF2 nuclear expression in patients with ESCC that was related to worse survival and poorer therapy outcomes. SLC7A11-mediated ferroptosis inhibition induced NRF2-associated radioresistance, highlighting potential of NRF2/SLC7A11/ferroptosis axis as future therapeutic targets against therapy resistance biomarker.

Keyphrases

oxidative stress
cell death
poor prognosis
binding protein
signaling pathway
high glucose
drug induced
type diabetes
mesenchymal stem cells
insulin resistance
free survival