Phase II prospective randomized trial of weight loss prior to radical prostatectomy.
Susanne M HenningColette GaletKiran GollapudiJoshua B ByrdPei LiangZhaoping LiTristan GroganDavid ElashoffClara E MagyarJonathan SaidPinchas CohenWilliam J AronsonPublished in: Prostate cancer and prostatic diseases (2017)
In summary, this short-term WL program prior to radical prostatectomy resulted in significantly more WL in the intervention vs. the control group and was accompanied by significant reductions in body fat mass, circulating triglycerides, and insulin. However, no significant changes were observed in malignant epithelium apoptosis or proliferation. Future studies should consider a longer term or more intensive weight loss intervention.
Keyphrases
- radical prostatectomy
- weight loss
- prostate cancer
- phase ii
- bariatric surgery
- randomized controlled trial
- clinical trial
- roux en y gastric bypass
- open label
- glycemic control
- gastric bypass
- type diabetes
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- quality improvement
- cell death
- cell cycle arrest
- double blind
- study protocol
- placebo controlled
- cell proliferation
- weight gain
- phase iii
- gestational age
- metabolic syndrome
- skeletal muscle
- insulin resistance