Association between Proton Pump Inhibitor Use and Risk of Incident Chronic Kidney Disease: Systematic Review and Meta-Analysis.

Song Peng AngJia Ee ChiaCarlos ValladaresShreya PatelDaniel GewirtzJose Iglesias

Published in: Biomedicines (2024)

Our multifaceted analysis showed that PPI use was associated with a higher incidence of CKD when compared to non-PPI use and H2RA use, respectively. These findings advocate for heightened vigilance and judicious use of long-term PPIs. Further large prospective longitudinal studies are warranted to validate these observations.

Keyphrases

chronic kidney disease
end stage renal disease
protein protein
rheumatoid arthritis
cardiovascular disease
risk factors
type diabetes
cross sectional
case control
ankylosing spondylitis
systemic sclerosis