Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7.

Bettina WöchtlFlorian GunzerWilhelm GernerHagen GasseMichaela KochZoltán BagóMartin GanterHerbert WeissenböckNora DinhoplSina M ColdeweyAlexandra von AltrockKarl-Heinz WaldmannArmin SaalmüllerKurt ZimmermannJörg SteinmannJan KehrmannLudger Klein-HitpassJochen BlomRalf EhrichtInes EngelmannIsabel Hennig-Pauka

Published in: Gut pathogens (2017)

Unexpectedly, E. coli O104:H4 infection caused only mild symptoms and minor changes in histology and blood parameters in piglets. Outcome of the infection trial does not reflect E. coli O104:H4 associated human disease as observed during the outbreak in 2011. The potential role of cells of the innate immune system for STEC related disease pathogenesis should be further elucidated.

Keyphrases

escherichia coli
immune response
induced apoptosis
endothelial cells
cell cycle arrest
signaling pathway
randomized controlled trial
phase iii
oxidative stress
staphylococcus aureus
cell proliferation
physical activity
risk assessment
depressive symptoms
open label
drug induced