Methylation-mediated silencing of miR-125a-5p facilitates breast cancer progression by inducing autophagy.

Fatemeh AhmadpourSomayeh IgderHossein Babaahmadi-RezaeiEhsan KhaliliMalek KananiVahid SoleimaniGhorban Mohammadzadeh

Published in: Molecular biology reports (2022)

Our data showed miR-125a expression was significantly decreased in tumor tissues due to its promoter hypermethylation. Overexpression of miR-125a was associated with a reduction in autophagy, which could provide a new therapeutic avenue for advanced-stage breast cancer treatment.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
cell death
endoplasmic reticulum stress
dna methylation
long noncoding rna
gene expression
signaling pathway
oxidative stress
transcription factor
electronic health record
genome wide
big data
binding protein
young adults
breast cancer risk
childhood cancer