Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.
Brian E FordShruti S ChachraAhmed AlshawiAlfie BrennanSuzannah J HarnorCeline CanoDavid J BakerDavid M SmithRebecca J FaircloughLoranne AgiusPublished in: Diabetes, obesity & metabolism (2020)
Chronic GKA treatment of C57BL/6 mice for 8 weeks activates liver ChREBP and improves the resilience of hepatocytes to compromised ATP homeostasis during high-substrate challenge. These changes are associated with raised mRNA levels of ChREBP-β and both catalytic subunits of AMP-activated protein kinase.