Gene's expression underpinning the divergent predictive value of [18F]F-fluorodeoxyglucose and prostate-specific membrane antigen positron emission tomography in primary prostate cancer: a bioinformatic and experimental study.
Matteo BaucknehtCecilia MariniVanessa CossuCristina CampiMattia RiondatoSilvia BrunoAnna Maria OrengoFrancesca VitaleSonia CartaSilvia ChiolaSabrina ChiesaAlberto MiceliFrancesca D'AmicoGiuseppe FornariniCarlo TerroneMichele PianaSilvia MorbelliAlessio SignoriPaola BarboroGianmario SambucetiPublished in: Journal of translational medicine (2023)
The overexpression of a functional network involving four glucose metabolism-related genes identifies a higher risk of disease progression since the earliest phases of PCa, in agreement with the acknowledged prognostic value of FDG PET imaging. By contrast, the prognostic value of PSMA PET imaging is independent of the expression of its encoding gene FOLH1. Instead, it is influenced by the protein docking to the cell membrane, regulating its accessibility to tracer binding.
Keyphrases
- pet imaging
- positron emission tomography
- prostate cancer
- computed tomography
- poor prognosis
- genome wide
- pet ct
- binding protein
- radical prostatectomy
- copy number
- protein protein
- magnetic resonance
- genome wide identification
- cell proliferation
- molecular dynamics
- long non coding rna
- molecular dynamics simulations
- dna methylation
- contrast enhanced
- gene expression
- dna binding
- genome wide analysis