Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells.
Nihal AlMuraikhiNuha AlmasoudSarah BinhamdanGhaydaa YounisDalia AliMuthurangan ManikandanRadhakrishnan VishnubalajiMuhammad AtteyaAbdulaziz SiyalMusaad AlfayezAbdullah AldahmashMoustapha KassemNehad M AlajezPublished in: Stem cells international (2019)
We identified SMO/Hedgehog antagonist (BMS-833923) as a powerful inhibitor of osteoblastic differentiation of hMSC that may be useful as a therapeutic option for treating conditions associated with high heterotopic bone formation and mineralization.