Differential blood miRNA expression in brain amyloid imaging-defined Alzheimer's disease and controls.

Helen Zong Ying WuAnbupalam ThalamuthuLesley ChengChristopher FowlerColin L MastersPerminder SachdevKaren A Mathernull null

Published in: Alzheimer's research & therapy (2020)

Blood miR-146b-5p and miR15b-5p showed consistent differential expression in AD compared to controls. Further replication and translational studies in strictly phenotyped cohorts are needed to establish their role as biomarkers for AD to have clinical utility.

Keyphrases

poor prognosis
high resolution
cognitive decline
resting state
binding protein
case control
multiple sclerosis
long non coding rna
blood brain barrier
fluorescence imaging
mild cognitive impairment