Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs.

Rui-Feng LiangWenjing GeBingjie LiWeifeng CuiXiaofan MaYuying PanGengsheng Li

Published in: Pharmaceutical biology (2022)

Evodiamine decreased the systemic exposure of pravastatin by up-regulating the expression of OATPs. These results provide a reference for further validation of this interaction in humans.

Keyphrases

poor prognosis
liver injury
drug induced
clinical evaluation