Hemizygous deletion of cyclin-dependent kinase inhibitor 2A/B with p16 immuno-negative and methylthioadenosine phosphorylase retention predicts poor prognosis in IDH-mutant adult glioma.
Ryosuke OtsujiNobuhiro HataHidetaka YamamotoDaisuke KugaRyusuke HataeYuhei SangatsudaYutaka FujiokaNaoki NoguchiAki SakoOsamu TogaoTadamasa YoshitakeAkira NakamizoMasahiro MizoguchiKoji YoshimotoPublished in: Neuro-oncology advances (2024)
hemizygous deletions exerted a negative impact on OS in astrocytoma. Immunohistochemistry of p16/MTAP can be utilized to validate hemizygous or homozygous deletions in combination with conventional molecular diagnosis.