Exploring the role of the inflammasomes on prostate cancer: Interplay with obesity.
Jesús M Pérez-GómezAntonio J Montero-HidalgoAntonio C Fuentes-FayosAndré Sarmento-CabralRocio Guzmán-RuizMaría M MalagónAura Dulcinea Herrera-MartínezManuel D GaheteRaul Miguel LuquePublished in: Reviews in endocrine & metabolic disorders (2023)
Obesity is a weight-related disorder characterized by excessive adipose tissue growth and dysfunction which leads to the onset of a systemic chronic low-grade inflammatory state. Likewise, inflammation is considered a classic cancer hallmark affecting several steps of carcinogenesis and tumor progression. In this regard, novel molecular complexes termed inflammasomes have been identified which are able to react to a wide spectrum of insults, impacting several metabolic-related disorders, but their contribution to cancer biology remains unclear. In this context, prostate cancer (PCa) has a markedly inflammatory component, and patients frequently are elderly individuals who exhibit weight-related disorders, being obesity the most prevalent condition. Therefore, inflammation, and specifically, inflammasome complexes, could be crucial players in the interplay between PCa and metabolic disorders. In this review, we will: 1) discuss the potential role of each inflammasome component (sensor, molecular adaptor, and targets) in PCa pathophysiology, placing special emphasis on IL-1β/NF-kB pathway and ROS and hypoxia influence; 2) explore the association between inflammasomes and obesity, and how these molecular complexes could act as the cornerstone between the obesity and PCa; and, 3) compile current clinical trials regarding inflammasome targeting, providing some insights about their potential use in the clinical practice.
Keyphrases
- weight loss
- weight gain
- insulin resistance
- prostate cancer
- metabolic syndrome
- oxidative stress
- high fat diet induced
- adipose tissue
- low grade
- type diabetes
- clinical trial
- body mass index
- radical prostatectomy
- clinical practice
- papillary thyroid
- high grade
- end stage renal disease
- physical activity
- dna damage
- newly diagnosed
- squamous cell
- poor prognosis
- ejection fraction
- squamous cell carcinoma
- prognostic factors
- endothelial cells
- cell proliferation
- lps induced
- human health
- inflammatory response
- immune response
- middle aged
- peritoneal dialysis
- patient reported outcomes
- phase ii