Review of the effects of vitexin in oxidative stress-related diseases.
Fatemeh BabaeiArmita MoafizadZahra DarvishvandMohammadreza MirzababaeiMahboobeh Ghasemzadeh RahbardarMarjan Nassiri-AslPublished in: Food science & nutrition (2020)
Vitexin is an apigenin flavone glycoside found in food and medicinal plants. It has a variety of pharmacological effects, including antioxidant, anti-inflammatory, anticancer, antinociceptive, and neuroprotective effects. This review study summarizes all the protective effects of vitexin as an antioxidant against reactive oxygen species, lipid peroxidation, and other oxidative damages in a variety of oxidative stress-related diseases, including seizure, memory impairment, cerebral ischemia, neurotoxicity, myocardial and respiratory injury, and metabolic dysfunction, with possible molecular and cellular mechanisms. This review describes any activation or inhibition of the signaling pathways that depend on the antioxidant activity of vitexin. More basic research is needed on the antioxidative effects of vitexin in vivo, and carrying out clinical trials for the treatment of oxidative stress-related diseases is also recommended.
Keyphrases
- oxidative stress
- anti inflammatory
- cerebral ischemia
- ischemia reperfusion injury
- induced apoptosis
- dna damage
- clinical trial
- diabetic rats
- subarachnoid hemorrhage
- signaling pathway
- left ventricular
- randomized controlled trial
- blood brain barrier
- risk assessment
- epithelial mesenchymal transition
- human health
- endoplasmic reticulum stress
- heat shock
- combination therapy