Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.
Parvez VoraMathieu SeyfridChitra VenugopalMaleeha A QaziSabra SalimRuth IsserlinMinomi SubapandithaErin O'FarrellSujeivan MahendramMohini SinghDavid BakhshinyanChirayu ChokshiNicole McFarlaneAnna Dvorkin-GhevaKevin R BrownNaresh MurtyJason MoffatGary D BaderSheila K SinghPublished in: Journal of neuro-oncology (2019)
Our work sheds light on the association of three genes with CD133-BMI1 circuitry, their importance as downstream effectors of the BMI1 signalling pathway, and their potential as future targets for tackling GBM treatment-resistant cell populations.
Keyphrases
- body mass index
- stem cells
- weight gain
- genome wide
- induced apoptosis
- endothelial cells
- cell therapy
- genome wide identification
- cell cycle arrest
- single cell
- dna methylation
- genome wide analysis
- gene expression
- transcription factor
- physical activity
- cell death
- oxidative stress
- pluripotent stem cells
- signaling pathway
- cell proliferation
- climate change
- pi k akt