Autoantibody Landscape in Patients with Advanced Prostate Cancer.
William S ChenWinston A HaynesRebecca WaitzKathy KamathAgustin Vega-CrespoRaunak ShresthaMinlu ZhangAdam FoyeIgnacio Baselga CarreteroIvan Perez GarcilazoMeng ZhangShuang G ZhaoMartin SjöströmDavid A QuigleyJonathan ChouTomasz M BeerMatthew B RettigMartin GleaveChristopher P EvansPrimo LaraKim N ChiRobert E ReiterJoshi J AlumkalAlan AshworthRahul AggarwalEric J SmallPatrick S DaughertyAntoni RibasDavid Y OhJohn C ShonFelix Y FengPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
We present the first large-scale profiling of autoantibodies in advanced prostate cancer, utilizing a new antibody profiling approach to reveal novel cancer-specific antigens and epitopes. Our study recovers antigens of known importance and identifies novel tumor-specific epitopes of translational interest.