Soluble Triggering Receptors Expressed on Myeloid Cells (sTREM) in Acute Ischemic Stroke: A Potential Pathway of sTREM-1 and sTREM-2 Associated with Disease Severity.
Greta SalafiaAngelica CarandinaRoberto Maria SaccoEvelyn FerriNicola MontanoBeatrice ArosioEleonora TobaldiniPublished in: International journal of molecular sciences (2024)
In 2022, stroke emerged as the most significant cerebrovascular disorder globally, causing 6.55 million deaths. Microglia, crucial for CNS preservation, can exacerbate brain damage in ischemic stroke by triggering neuroinflammation. This process is mediated by receptors on microglia, triggering receptors expressed on myeloid cells (TREM-1 and TREM-2), which have contrasting roles in neuroinflammation. In this study, we recruited 38 patients within 4.5 h from the onset of ischemic stroke. The degree of severity was evaluated by means of the National Institutes of Health Stroke Scale (NIHSS) at admission (T0) and after one week of ischemic events (TW) and the Modified Rankin Scale (mRS) at three months. The plasma concentration of TREMs (sTREM) was analyzed by next-generation ELISA at T0 and TW. The sTREM-1 concentrations at T0 were associated with mRS, while the sTREM-2 concentrations at T0 were associated with both the NIHSS at T0 and the mRS. A strong correlation between sTREM-1 and sTREM-2 was observed, suggesting a dependent modulation of the levels. This study provides insights into the potential pathway of TREM-1 and TREM-2 as a future biomarker for stratifying high-risk patients with ischemic stroke.
Keyphrases
- atrial fibrillation
- induced apoptosis
- cerebral ischemia
- end stage renal disease
- chronic kidney disease
- traumatic brain injury
- bone marrow
- inflammatory response
- cell cycle arrest
- healthcare
- oxidative stress
- acute myeloid leukemia
- public health
- lipopolysaccharide induced
- ejection fraction
- newly diagnosed
- randomized controlled trial
- blood brain barrier
- white matter
- neuropathic pain
- lps induced
- multiple sclerosis
- clinical trial
- peritoneal dialysis
- ischemia reperfusion injury
- signaling pathway
- patient reported outcomes
- immune response
- resting state
- subarachnoid hemorrhage
- risk assessment
- endoplasmic reticulum stress
- quality improvement
- spinal cord injury
- functional connectivity
- health promotion
- current status