An updated overview of recent and ongoing deep brain stimulation (DBS) trials in patients with dementia: a systematic review.

Giulia RemoliLeonardo TariciottiLuigi Gianmaria RemorePaolo PalmiscianoFrancesco SciancaleporeMarco CanevelliEleonora LacorteFulvio Da ReGiuseppe BrunoCarlo FerrareseIldebrando AppollonioMarco LocatelliNicola Vanacore

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)

The population investigated is small and heterogeneous, published results from clinical trials are under-represented, severe adverse events not negligible, and cognitive outcomes uncertain. Overall, the validity of these studies requires confirmation based on forthcoming higher-quality clinical trials.

Keyphrases

deep brain stimulation
clinical trial
parkinson disease
obsessive compulsive disorder
phase ii
mild cognitive impairment
early onset
cognitive impairment
open label
double blind
atomic force microscopy
quality improvement
randomized controlled trial
metabolic syndrome
drug induced
glycemic control