Cancer-associated fibroblast senescence and its relation with tumour-infiltrating lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma.

Chuan LanYuki KitanoYo-Ichi YamashitaTakanobu YamaoKiyoshi KajiyamaTomoharu YoshizumiKengo FukuzawaKeishi SugimachiYasuharu IkedaHiroshi TakamoriNobutomo MiyanariMasahiko HirotaHideo Baba

Published in: British journal of cancer (2021)

Cellular senescence, represented by CAV1 levels, may be a marker of CAFs and a prognostic indicator of ICC through Foxp3+ TIL regulation. CAV1 expression in CAFs can be a therapeutic target for ICC.

Keyphrases

dna damage
endothelial cells
poor prognosis
regulatory t cells
stress induced
peripheral blood
binding protein
long non coding rna
oxidative stress