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Novel ACTL7A variants in males lead to fertilization failure and male infertility.
Meng Wang
Juepu Zhou
Rui Long
Huizi Jin
Limin Gao
Lixia Zhu
Lei Jin
Published in:
Andrology (2023)
ACTL7A variants affected the expression and localization of actin-like protein 7A in the affected spermatozoa and subsequently decreased the expression of phospholipase C zeta 1, which caused fertilization failure and male infertility.
Keyphrases
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poor prognosis
copy number
polycystic ovary syndrome
long non coding rna
gene expression
metabolic syndrome
skeletal muscle