Gut dysbiosis in cutaneous T-cell lymphoma is characterized by shifts in relative abundances of specific bacterial taxa and decreased diversity in more advanced disease.
M J HooperT M LeWittY PangF L VeonG E ChlipalaL FefermanS J GreenD SweeneyK T BagnowskiM B BurnsP C SeedJ ChoiJ GuitartXiaolong Alan ZhouPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
Gut dysbiosis can be seen in patients with CTCL compared to healthy controls and is pronounced in more advanced CTCL. The taxonomic shifts associated with CTCL are similar to those previously reported in atopic dermatitis and opposite those of psoriasis, suggesting microbial parallels to the immune profile and skin barrier differences between these conditions. These findings may suggest new microbial disease biomarkers and reveal a new angle for intervention.