CRT non-responder to responder conversion rate in the MORE-CRT MPP Trial.
Christophe LeclercqHaran Burri FehraPeter Paul DelnoyChristopher Aldo RinaldiJohannes SperzelLeonardo CalòJoaquin Fernande ConchaAntonio FuscoFaisal Al SamadiKwangdeok LeeBernard ThibaultPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
Our trial shows that approximately 30% of patients, who do not respond to CRT in the first six months, experience significant reverse remodeling in the following six months. This finding suggests that CRT benefit may be delayed or slowly incremental in a relevant proportion of patients and that the percentage of CRT responders may be higher than what has been described in short/middle-term studies. MPP does not improve CRT response in non-responders to BiVP, even with MPP-AS.