New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice.
Edward O ListDarlene E BerrymanElizabeth A JensenPrateek KulkarniSavannah McKennaJohn J KopchickPublished in: Archives of endocrinology and metabolism (2020)
In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67.
Keyphrases
- growth hormone
- stem cells
- adipose tissue
- induced apoptosis
- gene expression
- cell cycle arrest
- heart failure
- white matter
- skeletal muscle
- bone marrow
- resting state
- wild type
- cell therapy
- signaling pathway
- oxidative stress
- bone loss
- fatty acid
- functional connectivity
- cerebral ischemia
- drug delivery
- bone regeneration
- pi k akt
- subarachnoid hemorrhage