Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes.
Giovanni TarantinoCarmine FinelliFranco ScopacasaFabrizio PasanisiFranco ContaldoDomenico CaponeSilvia SavastanoPublished in: Oxidative medicine and cellular longevity (2014)
The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease mirroring its reduced mitochondrial expression in an attempt to increase the fat oxidative capacity and then the mitochondrial function in liver and in muscle. SIRT4 modulates the metabolism of free fatty acids reducing their high circulating levels but, unfortunately, increasing ROS production. Great concentration of free fatty acids, released by adipose tissue, coupled with oxidative stress, directly results in endothelial dysfunction, early atherosclerosis, and coronary artery disease risk factor.
Keyphrases
- oxidative stress
- adipose tissue
- obese patients
- coronary artery disease
- fatty acid
- bariatric surgery
- ischemia reperfusion injury
- dna damage
- gastric bypass
- cardiovascular events
- risk factors
- roux en y gastric bypass
- weight loss
- skeletal muscle
- metabolic syndrome
- high fat diet
- type diabetes
- induced apoptosis
- diabetic rats
- climate change
- heart failure