Utilization of rGO-PEI-supported AgNPs for sensitive recognition of deltamethrin in human plasma samples: A new platform for the biomedical analysis of pesticides in human biofluids.
Bashir AdelMohsen JafariMohammad HasanzadehPublished in: Journal of molecular recognition : JMR (2021)
In this study, the rGO-PEI-AgNPs sensor was designed as a new effective platform to sensitive monitoring of deltamethrin in human plasma samples. For this purpose, reduced graphene oxide (rGO)-supported polyethylenimine (PEI) was used as a suitable substrate for dispersion of silver nanoparticles (AgNPs) as amplification and catalytic element. Therefore, a novel interface (rGO-PEI-AgNPs) was prepared by the fully electrochemical method on the surface of glassy carbon electrodes. The engineered nano-sensor showed a wide dynamic range of 10 nM to 1 mM and low limit of quantification (LLOQ) as 10 nM in human plasma sample, which revealed excellent analytical performance for the recognition of deltamethrin with high sensitivity and reproducibility through differential pulse voltammetry and square wave voltammetry techniques. The results confirm that rGO-PEI-AgNPs as a novel biocompatible interface can provide appropriate, reliable, affordable, rapid, and user-friendly diagnostic tools in the detection of deltamethrin in human real samples.
Keyphrases
- reduced graphene oxide
- silver nanoparticles
- gold nanoparticles
- endothelial cells
- aedes aegypti
- high throughput
- induced pluripotent stem cells
- photodynamic therapy
- label free
- loop mediated isothermal amplification
- pluripotent stem cells
- blood pressure
- ionic liquid
- risk assessment
- mass spectrometry
- liquid chromatography
- gas chromatography
- low cost
- simultaneous determination
- light emitting
- real time pcr
- tandem mass spectrometry