Cholesterol profiling reveals 7β-hydroxycholesterol as a pathologically relevant peripheral biomarker of Alzheimer's disease.

Junghee HaGo Eun KwonYumi SonSoo Ah JangSo Yeon ChoSoo Jin ParkHyunjeong KimJimin LeeJuseok LeeDongryul SeoMyeongjee LeeDo Yup LeeMan Ho ChoiEosu Kim

Published in: Psychiatry and clinical neurosciences (2024)

Our results suggest that 7β-OHC could serve as a convenient, peripheral biomarker of AD. As directly involved in AD pathogenesis, 7β-OHC assay may help actualize personalized medicine in a way to identify an at-risk subgroup as a candidate population for statin-based AD treatment.

Keyphrases

low density lipoprotein
cardiovascular disease
chemotherapy induced
high throughput
coronary artery disease
cognitive decline
single cell
randomized controlled trial
clinical trial
replacement therapy
combination therapy
phase iii
mild cognitive impairment
placebo controlled