The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria.
Vineet K SinghKuldeep SinghKyle BaumPublished in: Antioxidants (Basel, Switzerland) (2018)
Methionine sulfoxide reductases (MSRA1 and MSRB) are proteins overproduced in Staphylococcus aureus during exposure with cell wall-active antibiotics. Later studies identified the presence of two additional MSRA proteins (MSRA2 and MSRA3) in S. aureus. These MSR proteins have been characterized in many other bacteria as well. This review provides the current knowledge about the conditions and regulatory network that mimic the expression of these MSR encoding genes and their role in defense from oxidative stress and virulence.
Keyphrases
- staphylococcus aureus
- oxidative stress
- biofilm formation
- cell wall
- escherichia coli
- pseudomonas aeruginosa
- methicillin resistant staphylococcus aureus
- poor prognosis
- dna damage
- healthcare
- ischemia reperfusion injury
- transcription factor
- genome wide
- antimicrobial resistance
- induced apoptosis
- gene expression
- amino acid
- cystic fibrosis
- heat shock
- long non coding rna
- genome wide identification