Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia.

Eleni Karatza Jaydeep Sinha Patricia D Maglalang Andrea N Edginton Daniel Gonzalez

Published in: Clinical pharmacokinetics (2024)

The PBPK model helped assess the nonlinear dose-exposure relationship of VPA and the impact of albumin concentrations on the achievement of target exposure.

Keyphrases

young adults