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KAT5 Inhibitor NU9056 Suppresses Anaplastic Thyroid Carcinoma Progression through c-Myc/miR-202 Pathway.

Wenjing XuLiwei XieYingying YangJiayu XuShang CaiYe Tian
Published in: International journal of endocrinology (2022)
Our results indicated that NU9056 targets KAT5, shortens c-Myc half-life, subsequently downregulates miR-202 expression, and results in the suppression of ATC cells. Overall, KAT5 could be a potential target for clinical treatment for ATC.
Keyphrases
  • long non coding rna
  • cell proliferation
  • poor prognosis
  • long noncoding rna
  • induced apoptosis
  • cell cycle arrest
  • signaling pathway
  • endoplasmic reticulum stress
  • oxidative stress
  • risk assessment
  • climate change