Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection.

Michelle N VuDorothea R MorrisR Elias AlvaradoKumari G LokugamageYiyang ZhouLeah K EstesAlyssa M McLelandCraig SchindewolfJessica A PlanteYani P AhearnAngelica L MorganWilliam M MeyersJordan T MurrayScott C WeaverDavid H WalkerWilliam K RussellAndrew L RouthKenneth S PlanteVineet Menachery

Published in: bioRxiv : the preprint server for biology (2023)

Spike substitution N679K attenuates SARS-CoV-2 Omicron variants by decreasing spike protein and has potential implications for immunity and vaccine efficacy.

Keyphrases

sars cov
respiratory syndrome coronavirus
copy number
protein protein
risk assessment
climate change
dna methylation
gene expression
small molecule
binding protein