Heterogeneous Effects of CPAP in Non-Sleepy OSA on CVD Outcomes: Post-hoc Machine Learning Analysis of the ISAACC Trial (ECSACT Study).
Oren CohenManuel Sánchez-de-la-TorreZainab Al-TaieSamira KhanVaishnavi KundelJason C KovacicEsther Gracia-LavedanJordi De BatlleGirish NadkarniFerran BarbéMayte Suárez-FariñasNeomi A ShahPublished in: Annals of the American Thoracic Society (2024)
We discovered subgroups of non-sleepy OSA participants within the ISAACC study with heterogeneous effects of CPAP. Among the training dataset, those with longer OSA event duration and hypercholesterolemia had nearly 2.5-times more CVD events with CPAP compared to UC, while those with shorter OSA event duration had roughly half the rate of CVD events if randomized to CPAP.