Spontaneous Graft-Induced Dyskinesias Are Independent of 5-HT Neurons and Levodopa Priming in a Model of Parkinson's Disease.

Emma L LaneDavid J HarrisonElena Ramos-VarasRachel HillsSophie TurnerMariah J Lelos

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

These findings argue against current thinking that rats do not develop spontaneous GID and that serotonin neurons are causative, rather indicating that GID can be induced in rats by hESC-derived dopamine grafts and, critically, can occur independently of both previous levodopa exposure and grafted serotonin neurons. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

spinal cord
high glucose
diabetic rats
parkinson disease
deep brain stimulation
drug induced
systematic review
endothelial cells
randomized controlled trial
spinal cord injury