Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy.
Brennetta J CrenshawLeandra B JonesCourtnee' R BellSanjay KumarQiana L MatthewsPublished in: Biomedicines (2019)
Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause respiratory infections. These viruses are particularly pathogenic in healthy and immune-compromised individuals, and currently, no adenovirus vaccine is available for the general public. The purpose of this review is to describe (i) the epidemiology and pathogenicity of human adenoviruses, (ii) the biological role of adenovirus vectors in gene therapy applications, and (iii) the potential role of exosomes in adenoviral infections.
Keyphrases
- gene therapy
- endothelial cells
- induced pluripotent stem cells
- healthcare
- pluripotent stem cells
- stem cells
- mesenchymal stem cells
- mental health
- biofilm formation
- breast cancer cells
- circulating tumor
- pseudomonas aeruginosa
- cell proliferation
- signaling pathway
- escherichia coli
- risk assessment
- binding protein
- human health
- pi k akt