Targeting Metalloenzymes: The "Achilles' Heel" of Viruses and Parasites.
Dimitrios MoianosGeorgia-Myrto PriftiMaria MakriGrigoris ZoidisPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as Trypanosoma brucei and Trypanosoma cruzi .
Keyphrases
- human health
- infectious diseases
- nucleic acid
- public health
- trypanosoma cruzi
- risk assessment
- endothelial cells
- cancer therapy
- climate change
- plasmodium falciparum
- signaling pathway
- sars cov
- induced pluripotent stem cells
- stem cells
- binding protein
- protein protein
- pluripotent stem cells
- small molecule
- drug delivery
- cell therapy