Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity.

Beatriz G Perez-NievasLouisa JohnsonPaula Beltran-LoboMartina M HughesLuciana GammallieriFrancesca TarsitanoMonika A MyszczynskaIrina Vazquez-VillasenorMaria Jimenez-SanchezClaire TroakesStephen B WhartonLaura FerraiuoloWendy Noble

Published in: Journal of neuroinflammation (2021)

Our data indicate that astrocytes exacerbate the synaptotoxic effects of Aβ via interactions of astrocytic CXCL1 and neuronal CXCR2 receptors, highlighting this chemokine-receptor pair as a novel target for therapeutic intervention in AD.

Keyphrases

randomized controlled trial
high glucose
diabetic rats
electronic health record
big data
drug induced
binding protein
data analysis
subarachnoid hemorrhage
artificial intelligence
stress induced